This article focuses on the experiences of becoming and being mothers for lesbian co-parents who have children via donor insemination. Rather than the presence of children incorporating lesbians into the mainstream as “honorary heterosexuals,” the author argues that lesbian parenting represents a radical and radicalizing challenge to heterosexual norms that govern parenting roles and identities. It undermines traditional notions of the family and the heterosexual monopoly of reproduction. The same-sex context together with successful collaboration with donors supports the refashioning of (...) kinship relationships. An attentiveness to the gender dynamics of sexuality illuminates further contestations. The author argues that their structural similarities as women place them in contradiction with dominant gender practices enacted in heterosexual relationships. This facilitates the evaluation and negotiation of more egalitarian approaches to work and parenting, and through their operationalization, much of the logic supporting conventional divisions of labor is undermined. (shrink)

Despite its diminished importance amongst philosophers, the deductive-nomological framework is still important to contemporary behavioral scientists. Behavioral theorists operating within this framework must be careful to distinguish between nesting and chaining. Explanations are chained when the explanandum sentence of one explanation is one of the antecedent conditions of another. They are nested when one of the antecedent conditions or the explanandum sentence of one explanation is one of the covering laws of another. Confusion between nesting and chaining leads to explanation (...) nests that cannot be nomologically entrenched. They cannot, even in principle, be logically connected to laws arising from other sciences. This hazard should be particularly important for evolutionary psychologists to avoid, since many evolutionary psychologists tend to see themselves as dedicated to both nomological entrenchment and cognitive functionalist models. The hazard can be avoided if the intentional constructs of the behavioral sciences are construed not as ineffable and inaccessible antecedent conditions, but as complex, law-like patterns in behavior. (shrink)

Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predomi- nantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase ‘paradigm shift’ in (...) his groundbreaking book The Structure of Scientific Revolutions. He argued that the arrival of the new and often incompatible idea forms the core of a new paradigm, the birth of an entirely new way of thinking. This article discusses whether Steiner and col- leagues truly brought about a paradigm shift in oncological surgery. By rejecting the principle of en block resection and by replacing it with the belief that not only is it oncologically safe to cut through the substance of the tumour but in doing so one can actually achieve better results, Steiner was able to truly revolutionise the man- agement of laryngeal cancer. Even though within this article the repercussions of his insight are limited to the upper aerodigestive tract oncological surgery, his willingness to question other peoples’ dogma makes his contribution truly a genuine paradigm shift. (shrink)

This paper examines beliefs about four aspects of ethical leadership – Character/Integrity, Altruism, Collective Motivation and Encouragement – in Germany and the United States using data from Project GLOBE (Global Leadership and Organizational Behavior Effectiveness) and a supplemental analysis. Within the context of a push toward convergence driven by the demands of globalization and the pull toward divergence underpinned by different cultural values and philosophies in the two countries, we focus on two questions: Do middle managers from the United States (...) and Germany differ in their beliefs about ethical leadership? And, do individuals from these two countries attribute different characteristics to ethical leaders? Results provide evidence that while German and US middle managers, on average, differed in the degree of endorsement for each aspect, they each endorsed Character/Integrity, Collective Motivation and Encouragement as important for effective leadership and had a more neutral view of the importance of Altruism . The findings are reviewed within the social-cultural context of each country. (shrink)

This paper examines beliefs about four aspects of ethical leadership –Character/Integrity, Altruism, Collective Motivation and Encouragement– in Germany and the United States using data from Project GLOBE (Global Leadership and Organizational Behavior Effectiveness) and a supplemental analysis. Within the context of a push toward convergence driven by the demands of globalization and the pull toward divergence underpinned by different cultural values and philosophies in the two countries, we focus on two questions: Do middle managers from the United States and Germany (...) differ in their beliefs about ethical leadership? And, do individuals from these two countries attribute different characteristics to ethical leaders? Results provide evidence that while German and US middle managers, on average, differed in the degree of endorsement for each aspect, they each endorsed Character/Integrity, Collective Motivation and Encouragement as important for effective leadership and had a more neutral view of the importance of Altruism. The findings are reviewed within the social-cultural context of each country. (shrink)

The motto of the Royal Society—Nullius in verba—was intended to highlight the members’ rejection of received knowledge and the new place they afforded direct empirical evidence in their quest for genuine, useful knowledge about the world. But while many studies have raised questions about the construction, reception and authentication of knowledge, Evidence in the Age of the New Sciences is the first to examine the problem of evidence at this pivotal moment in European intellectual history. What constituted evidence—and for whom? (...) Where might it be found? How should it be collected and organized? What is the relationship between evidence and proof? These are crucial questions, for what constitutes evidence determines how people interrogate the world and the kind of arguments they make about it. In this important new collection, Lancaster and Raiswell have assembled twelve studies that capture aspects of the debate over evidence in a variety of intellectual contexts. From law and theology to geography, medicine and experimental philosophy, the chapters highlight the great diversity of approaches to evidence-gathering that existed side by side in the sixteenth and seventeenth centuries. In this way, the volume makes an important addition to the literature on early science and knowledge formation, and will be of particular interest to scholars and advanced students in these fields. (shrink)

Facial appearance changes with age and health affecting skin color as well as facial and head hair. Yet somehow the brain is able to see past shared structure and dynamic deformations to focus on subtle details that distinguish one face from another. This article argues that the brain takes an efficient approach to this problem using prior knowledge about the structure of faces in its analysis. It employs intrinsic norms to focus on subtle variations in the shared face configuration that (...) differentiate one face from another. The study reviews evidence that the brain uses multiple norms to extract face identity that these norms are shaped by visual experience, and that norm-based coding is well-suited to meeting the challenges of image-based face perception mentioned above. By encoding faces with reference to stored perceptual norms the visual system can focus on what is unique to each individual, allowing for the discrimination of thousands of faces despite their similarity. (shrink)

Our objective is to test an optimality model of human fertility that specifies the behavioral requirements for fitness maximization in order (a) to determine whether current behavior does maximize fitness and, if not, (b) to use the specific nature of the behavioral deviations from fitness maximization towards the development of models of evolved proximate mechanisms that may have maximized fitness in the past but lead to deviations under present conditions. To test the model we use data from a representative sample (...) of 7,107 men living in Albuquerque, New Mexico, between 1990 and 1993. The model we test proposes that low fertility in modern settings maximizes number of grandchildren as a result of a trade-off between parental fertility and next generation fertility. Results do not show the optimization, although the data do reveal a trade-off between parental fertility and offspring education and income.We propose that two characteristics of modern economies have led to a period of sustained fertility reduction and to a corresponding lack of association between income and fertility. The first is the direct link between costs of investment and wage rates due to the forces of supply and demand for labor in competitive economies. The second is the increasing emphasis on cumulative knowledge, skills, and technologies in the production of resources. Together they produce historically novel conditions. These two features of modern economies may interact with evolved psychological and physiological mechanisms governing fertility and parental investment to produce behavior that maximizes the economic productivity of lineages at the expense of fitness. If cognitive processes evolved to track diminishing returns to parental investment and if physiological processes evolved to regulate fertility in response to nutritional state and patterns of breast feeding, we might expect non-adaptive responses when returns from parental investment do not diminish until extremely high levels are reached. With high economic payoffs from parental investment, people have begun to exercise cognitive regulation of fertility through contraception and family planning practices. Those cognitive processes maynot have evolved to handle fitness trade-offs between fertility and parental investment. (shrink)

This paper establishes the 'emblematic' use of natural history as a propaedeutic to self-betterment in the Renaissance; in particular, in the natural histories of Gessner and Topsell, but also in the works of Erasmus and Rabelais. Subsequently, it investigates how Francis Bacon's conception of natural history is envisaged in relation to them. The paper contends that, where humanist natural historians understood the use of natural knowledge as a preliminary to individual improvement, Bacon conceived self-betterment foremost as a means to Christian (...) charity, or social-betterment. It thus examines the transformation of the moralizing aspect of Renaissance natural history in Bacon's conception of his Great Instauration. (shrink)

Despite recent advances in HIV prevention and treatment, high HIV incidence persists among people who inject drugs. Difficult legal and political environments and lack of services for PWID likely contribute to high HIV incidence. Some advocates question whether any HIV prevention research is ethically justified in settings where healthcare system fails to provide basic services to PWID and where implementation of research findings is fraught with political barriers. Ethical challenges in research with PWID include concern about whether research evidence will (...) be translated into practice; concerns that research might exacerbate background risks; and ethical challenges regarding the standard of HIV prevention in research. While these questions arise in other research settings, for research with PWID, these questions are especially controversial. This paper analyses four ethical questions in determining whether research could be ethically acceptable: Can researchers ensure that research does not add to the burden of social harms and poor health experienced by PWID? Should research be conducted in settings where it is uncertain whether research findings will be translated into practice? When best practices in prevention and care are not locally available, what standard of care and prevention is ethically appropriate? Does the conduct of research in settings with oppressive policies constitute complicity? We outline specific criteria to address these four ethical challenges. We also urge researchers to join the call to action for policy change to provide proven safe and effective HIV prevention and harm reduction interventions for PWID around the world. (shrink)

Despite recent advances in HIV prevention and treatment, high HIV incidence persists among people who inject drugs. Difficult legal and political environments and lack of services for PWID likely contribute to high HIV incidence. Some advocates question whether any HIV prevention research is ethically justified in settings where healthcare system fails to provide basic services to PWID and where implementation of research findings is fraught with political barriers. Ethical challenges in research with PWID include concern about whether research evidence will (...) be translated into practice; concerns that research might exacerbate background risks; and ethical challenges regarding the standard of HIV prevention in research. While these questions arise in other research settings, for research with PWID, these questions are especially controversial. This paper analyses four ethical questions in determining whether research could be ethically acceptable: Can researchers ensure that research does not add to the burden of social harms and poor health experienced by PWID? Should research be conducted in settings where it is uncertain whether research findings will be translated into practice? When best practices in prevention and care are not locally available, what standard of care and prevention is ethically appropriate? Does the conduct of research in settings with oppressive policies constitute complicity? We outline specific criteria to address these four ethical challenges. We also urge researchers to join the call to action for policy change to provide proven safe and effective HIV prevention and harm reduction interventions for PWID around the world. (shrink)

This paper aims to take the measure of the strand of early modern anti-clericalism that was conveyed by the term “priestcraft”. Priestcraft amounted to the claim that priests had usurped civil power and accumulated material wealth by systematically deceiving the laity and its secular rulers. Religion as it was practised and avowed by believers in early modern Europe was left tainted by this charge since manifold aspects of religious practice and belief fell under the pall of the suspicion that they (...) were merely part of the ruse perpetrated through the centuries by greedy and power-hungry priests. While the English language was particularly effective in condensing this claim into the term in question, mistrust of the clergy informed numerous discourses unfolding in diverse confessional and intellectual contexts. The present article seeks to draw attention to the thematic richness of priestcraft as an object of historical inquiry by identifying the multiple ways in which this trope made its presence felt in the early modern world. (shrink)

Abstract. This paper examines the impact of two formalizations of evolutionary biology on the antiselectionist critiques of the Intelligent Design (ID) movement. It looks first at attempts to apply the syntactic framework of the physical sciences to biology in the twentieth century, and to their effect upon the ID movement. It then examines the more heuristic account of biological-theory structure, namely, the semantic model. Finally, it concludes by advocating the semantic conception and emphasizing the problems that the semantic model creates (...) for ID's negative and positive theses. (shrink)

The book investigates the ways in which state-centred approaches to international relations have limited our understanding of global, political, economic and cultural processes. By assessing a wide range of such state-centred work, Youngs identifies the challenges we must address to grasp the complexity of the contemporary world.

Christine Jackson has succeeded in writing the modern biography of Edward Herbert long sought by early modern scholars. Jackson’s Courtier, Scholar, and Man of the Sword paints a rich picture of Ed...

This book offers a comprehensive and unitary study of the philosophy of Francis Bacon, with special emphasis on the medical, ethical and political aspects of his thought. It presents an original interpretation focused on the material conditions of nature and human life. In particular, coverage in the book is organized around the unifying theme of Bacon’s notion of appetite, which is considered in its natural, ethical, medical and political meanings. The book redefines the notions of experience and experiment in Bacon’s (...) philosophy of nature, shows the important presence of Stoic themes in his work as well as provides an original discussion of the relationships between natural magic, prudence and political realism in his philosophy. Bringing together scholarly expertise from the history of philosophy, the history of science and the history of literature, this book presents readers with a rich and diverse contextualization of Bacon’s philosophy. (shrink)

I should like to offer my greatest thanks to Paul Griffiths for providing the opportunity for this exchange, and to commentators Gillian Brown, Steven Fuller, Stefan Linquist, and Erika Milam for their generous and thought-provoking comments. I shall do my best in this space to respond to some of their concerns.

Despite the increasingly multinational nature of the workplace, there have been few studies of the convergence and divergence in beliefs about ethics-based leadership across cultures. This study examines the meaning of ethical and unethical leadership held by managers in six societies with the goal of identifying areas of convergence and divergence across cultures. More specifically, qualitative research methods were used to identify the attributes and behaviors that managers from the People’s Republic of China (the PRC), Hong Kong, the Republic of (...) China (Taiwan), the United States (the U.S.), Ireland, and Germany attribute to ethical and unethical leaders. Across societies, six ethical leadership themes and six unethical leadership themes emerged from a thematic analysis of the open-ended responses. Dominant themes for ethical and unethical leadership for each society are identified and examined within the context of the core cultural values and practices of that society. Implications for theory, research, and management practice are discussed. (shrink)

This article advances the theoretical and practical value of workplace spirituality by drawing on person–organization (PO) fit theory and transpersonal psychology to investigate three questions: (a) What antecedents lead individuals and organizations to seek and foster workplace spirituality? (b) What are the perceived spiritual needs of individuals, and how are those needs fulfilled in the workplace? and (c) What are the consequences of meeting spiritual needs as individuals perceive them? Using constructivist grounded theory, analysis of interview data from thirty-four participants (...) located in organizations across the Netherlands, Ireland, the United Kingdom, and Portugal led to development of a workplace spirituality, PO fit model in which we propose reconciling self as a core factor of workplace spirituality. We note how through the process of reconciling self, workplace spirituality is related to meaning making and how an individual perceives their work environment as conducive to self-expression and inner purpose. Practical and theoretical implications are discussed, as are limitations of the study and ideas for future research. (shrink)

In crafting our paper on addressing the ethical challenges in HIV prevention research with people who inject drugs,1 we had hoped to stimulate further discussion and deliberation about the topic. We are pleased that three commentaries on our paper have begun this process.2 3 4 The commentaries rightly bring up important issues relating to community engagement and problems in translating research into practice in the fraught environments in which PWID face multiple risks. These risks include acquisition of HIV as well (...) as criminalisation, stigma and lack of access to needed healthcare, prevention and social services. We take this opportunity to respond to the excellent points raised by the commentators. All of the commentaries support our emphasis on robust community engagement with PWID and other stakeholders in designing and conducting HIV prevention research, but urge us to go farther. Wolfe highlights the difficulty of even engaging with community members in oppressive settings, where authorities severely restrict civil liberties of PWID so that even discussing issues related to drug use and enforcement may place individuals at risk. To overcome such limitations, he appropriately suggests interviewing confidentially those who have previously been detained in closed settings as part of the community engagement process. Similarly, Wolfe observes that critical issues can be overlooked with a narrow focus on study procedures if contextual factors before, during or after a study are ignored. For example, he cites the risk of overdose for study participants who have been abstinent during a study and subsequently resume injecting when the study concludes. These kinds of risks may not be obvious …. (shrink)

In crafting our paper on addressing the ethical challenges in HIV prevention research with people who inject drugs, 1 we had hoped to stimulate further discussion and deliberation about the topic. We are pleased that three commentaries on our paper have begun this process. 2 3 4 The commentaries rightly bring up important issues relating to community engagement and problems in translating research into practice in the fraught environments in which PWID face multiple risks. These risks include acquisition of HIV (...) as well as criminalisation, stigma and lack of access to needed healthcare, prevention and social services. We take this opportunity to respond to the excellent points raised by the commentators. All of the commentaries support our emphasis on robust community engagement with PWID and other stakeholders in designing and conducting HIV prevention research, but urge us to go farther. Wolfe highlights the... (shrink)

Why is it important for people to agree on and articulate shared reasons for just laws, rather than whatever reasons they personally find compelling? What, if any, practical role does public reason play in liberal democratic politics? We argue that the practical role of public reason can be better appreciated by examining the confluence of normative and positive political theory; the former represented here by liberal social contract theory of John Rawls and others, and the latter by rational choice or (...) game theory. Citizens in a diverse society face a practical as well as a moral problem. How can they have confidence that others will reciprocate their commitment to supporting governing principles that depart from their own ideal conceptions of truth and value in order to be reasonable to all? Citizens face a practical problem of mutual assurance that public reason helps them solve, and solve as a matter of common knowledge. The solution, on both views, requires citizens’ reciprocal commitment to basing law on a system of shared reasons. Both views place public reason at the core of liberal democratic politics in conditions of diversity, and for quite similar reasons. Our argument illustrates the complementary roles of positive and values-based analysis in constitutional design. (shrink)

Pragmatic language competence plays a central role in how aviation flight crews perform crew resource management ; this competence significantly affects aviation safety. This paper contributes to existing literature on interventionist applications of conversation analysis by defining and evaluating a novel collaborative transcription and repair based learning method for aviation CRM learning. CTRBL was evaluated using a quantitative quasi-­experimental repeated-measure design with 42 novice, university pilots. Results support that CTRBL is an effective, low-resource CRM learning method that will benefit from (...) exploratory applications and further study in pragmatics, aviation, and other sociotechnical domains. The views in this article were the result of independent research of the authors. Views herein do not necessarily represent the views of the National Transportation Safety Board or the United States. (shrink)

Socioeconomic differences in behaviour are pervasive and well documented, but their causes are not yet well understood. Here, we make the case that a cluster of behaviours is associated with lower socioeconomic status, which we call “the behavioural constellation of deprivation.” We propose that the relatively limited control associated with lower SES curtails the extent to which people can expect to realise deferred rewards, leading to more present-oriented behaviour in a range of domains. We illustrate this idea using the specific (...) factor of extrinsic mortality risk, an important factor in evolutionary theoretical models. We emphasise the idea that the present-oriented behaviours of the constellation are a contextually appropriate response to structural and ecological factors rather than a pathology or a failure of willpower. We highlight some principles from evolutionary theoretical models that can deepen our understanding of how socioeconomic inequalities can become amplified and embedded. These principles are that small initial disparities can lead to larger eventual inequalities, feedback loops can embed early-life circumstances, constraints can breed further constraints, and feedback loops can operate over generations. We discuss some of the mechanisms by which SES may influence behaviour. We then review how the contextually appropriate response perspective that we have outlined fits with other findings about control and temporal discounting. Finally, we discuss the implications of this interpretation for research and policy. (shrink)

Gillian Brock develops a model of global justice that takes seriously the moral equality of all human beings notwithstanding their legitimate diverse identifications and affiliations. She addresses concerns about implementing global justice, showing how we can move from theory to feasible public policy that makes progress toward global justice.

Offering an engaging and accessible portrait of the current state of the field, Philosophy of Science: A New Introduction shows students how to think philosophically about science and why it is both essential and fascinating to do so. Gillian Barker and Philip Kitcher reconsider the core questions in philosophy of science in light of the multitude of changes that have taken place in the decades since the publication of C.G. Hempel's classic work, Philosophy of Natural Science —both in the (...) field and also in history and sociology of science and the sciences themselves. They explore how philosophical questions are connected to vigorous current debates—including climate change, science and religion, race, intellectual property rights, and medical research priorities—showing how these questions, and philosophers' attempts to answer them, matter in the real world. Featuring numerous illustrative examples and extensive further reading lists, Philosophy of Science: A New Introduction is ideal for courses in philosophy of science, history and philosophy of science, and epistemology/theory of knowledge. It is also compelling and illuminating reading for scientists, science students, and anyone interested in the natural sciences and in their place in global society today. (shrink)

Melusine the Serpent Goddess in Myth and Literature examines how women were once worshipped as the life force, but later suppressed with the introduction of monotheism and a changing attitude regarding the sexes. It connects the literary conception of the Melusine story to myths and legends of the snake or dragon goddess, from ancient to contemporary times.

In recent years, housing costs have outpaced incomes in the United States, resulting in millions of eviction filings each year. Yet no study has examined the link between eviction and voting. Drawing on a novel data set that combines tens of millions of eviction and voting records, this article finds that residential eviction rates negatively impacted voter turnout during the 2016 presidential election. Results from a generalized additive model show eviction’s effect on voter turnout to be strongest in neighborhoods with (...) relatively low rates of displacement. To address endogeneity bias and estimate the causal effect of eviction on voting, the analysis treats commercial evictions as an instrument for residential evictions, finding that increases in neighborhood eviction rates led to substantial declines in voter turnout. This study demonstrates that the impact of eviction reverberates far beyond housing loss, affecting democratic participation. (shrink)

Between Feminism and Materialism is a bold attempt to make sense of the relationship between feminist theory and capitalism. Addressing a number of philosophical problems that have engaged feminists over the last few decades - universals and reason, nature and essentialism, identity and non-identity, sex and gender, power and patriarchy, local and global - this innovative book breaks through feminist waves and explains the paradoxes of feminist theory by demonstrating the on-going relevance of dialectics and the concepts of exploitation, ideology, (...) and reification. Drawing on first, second and third 'waves' of feminist theory, this exciting combination of existentialism, phenomenology and critical theory delivers a problem-based, micro-political and coalitional feminism ready to respond to the challenges presented by our thoroughly modern times. (shrink)

This paper is about the putative theoretical virtue of strength, as it might be used in abductive arguments to the correct logic in the epistemology of logic. It argues for three theses. The first is that the well-defined property of logical strength is neither a virtue nor a vice, so that logically weaker theories are not—all other things being equal—worse or better theories than logically stronger ones. The second thesis is that logical strength does not entail the looser characteristic of (...) scientific strength, and the third is that many modern logics are on a par—or can be made to be on a par—with respect to scientific strength. (shrink)

The analytic/synthetic distinction looks simple. It is a distinction between two different kinds of sentence. Synthetic sentences are true in part because of the way the world is, and in part because of what they mean. Analytic sentences - like all bachelors are unmarried and triangles have three sides - are different. They are true in virtue of meaning, so no matter what the world is like, as long as the sentence means what it does, it will be true. -/- (...) This distinction seems powerful because analytic sentences seem to be knowable in a special way. One can know that all bachelors are unmarried, for example, just by thinking about what it means. But many twentieth-century philosophers, with Quine in the lead, argued that there were no analytic sentences, that the idea of analyticity didn't even make sense, and that the analytic/synthetic distinction was therefore an illusion. Others couldn't see how there could fail to be a distinction, however ingenious the arguments of Quine and his supporters. -/- But since the heyday of the debate, things have changed in the philosophy of language. Tools have been refined, confusions cleared up, and most significantly, many philosophers now accept a view of language - semantic externalism - on which it is possible to see how the distinction could fail. One might be tempted to think that ultimately the distinction has fallen for reasons other than those proposed in the original debate. -/- In Truth in Virtue of Meaning, Gillian Russell argues that it hasn't. Using the tools of contemporary philosophy of language, she outlines a view of analytic sentences which is compatible with semantic externalism and defends that view against the old Quinean arguments. She then goes on to draw out the surprising epistemological consequences of her approach. (shrink)

Published in France in 1980, _Marine Lover_ is the first in a trilogy in which Luce Irigaray links the interrogation of the feminine in post-Hegelian philosophy with a pre-Socratic investigation of the elements. Irigaray undertakes to interrogate Nietzche, the grandfather of poststructuralist philosophy, from the point of view of water. According to Irigaray, water is the element Nietzsche fears most. She uses this element in her narrative because for her there is a complex relationship between the feminine and the fluid. (...) Irigaray's method is to engage in an amorous dialogue with the male philosopher. In this dialogue, she ruptures conventional discourse and writes in a lyrical style that defies distinction between theory, fiction, and philosophy. (shrink)

Collagen is the most abundant vertebrate protein and forms a stable fibrous architecture in connective tissues, such as bone, cartilage, skin and tendon. Much recent research has been directed towards an understanding of the molecular and cellular mechanisms involved in the synthesis and degradation of collagen, because a change in the normal balance, or an increased destruction of collagen, can cause loss of function of specialized tissues. This short review attempts to summarize present knowledge about the proteolytic destruction of collagen (...) and the exciting new work on the factors that are emerging as important controlling agents. An understanding of the regulatory processes is yielding some important clues regarding the levels at which they can fail in pathological conditions and we speculate about evolving strategies for preventing uncontrolled resorption. (shrink)